"effect of apamin on tolerance to cocaine-induced locomotor activity in mice"
نویسندگان
چکیده
in the present study, the effect of apamin (potassium channel blocker) on tolerance to cocaine-induced locomotor activity in mice has been investigated. locomotor activity was measured by locomotor activity meter, animax, type s (lkb, farrad). intraperitoneal (ip) injection of different doses of cocaine (2.5, 5, 10 and 15 mg/kg) produced dose-dependent locomotor activity in mice.animals were treated with a dose of cocaine (60 mg/kg, ip) once daily, for 2, 3 or 4 days in order to produce tolerance to cocaine-induced locomotion. twenty-four hours after the last dose of cocaine, locomotor activity induced by a test dose of cocaine (10 mg/kg) was assessed. animals pretreated with apamin (0.1 mg/kg) 30 min before the test dose of cocaine had a decreased cocaine response. however, daily treatment of animals with apamin (0.1 mg/kg), 30 min after cocaine (60 mg/kg) for 3 days (during development of tolerance to cocaine-induced locomotion), did not alter the cocaine effect. single administration of apamin to mice did not cause any response. it is concluded that, apamin as a potassium channels blocker may decrease tolerance to cocaine-induced locomotion due to blockade of potassium channels.
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عنوان ژورنال:
acta medica iranicaجلد ۴۲، شماره ۲، صفحات ۷۸-۸۲
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